Researchers at Cedars-Sinai Medical Center tested the drug Tadalafil (sold as erectile dysfunction drug under the brand name Cialis) for men with Becker muscular dystrophy, one of nine types of muscular dystrophy, a group of hereditary muscle diseases to spend.
Here is a small description of planned research, Dr. Ronald G. Victor cedars and colleagues, funded by muscular dystrophy Assn. Twenty-four men with Becker or receive two doses of placebo or medication, and researchers will measure the degree of blood flow to the muscles that occurs when people exercise. According to a study in which mice with muscular dystrophy version of the animal can exercise more vigorously and with less muscle damage, when they received the drug.
With Tadalafil dilates blood vessels, and after examining the damage to the muscles of muscular dystrophy in mice, apparently due to a lack of blood supply, the court makes any sense.
And if so, it will be only one of a number of potential medical use of drugs for erectile dysfunction, who hail from the nearest full circle it seems.
Here are some facts about the history of medicine published in 2006 in the journal Nature Reviews Drug Discovery. (Sorry, but the journal needs to pay more than the abstract.)
The first of these drugs, sildenafil (Viagra) has been bumped to early human trials of potential drugs angina (at the time simply known as UK-92, 480) scientists from the pharmaceutical company Pfizer. The researchers found that people in the trial were reporting erections.
Zatsikavyvshys, scientists have begun testing designed specifically to test the effect of sex, in which erection was measured using the "device Rigiscan" - a loop located on the penis, to assess how hard, and they received direct sexual stimulation.
(Even later, "International index of erectile function were developed and used in clinical trials.)
Since 2005, sildenafil has been approved by the FDA under the name Revatio for the treatment of pulmonary hypertension, the condition of high blood pressure in the pulmonary artery.
And the authors of Nature Reviews Drug Discovery point for research, sildenafil and similar drugs could potentially help diseases such as congestive heart failure, hypertension, stroke and certain other lung diseases.
"Moreover, they write," many years ago left the original instructions, a single dose of sildenafil was shown to extend the deadline for the introduction of men with angina.
And again: "While these results may seem far removed from each other and all the disorders
described above, in reality is characterized by regional deficiencies in blood.
среда, 24 марта 2010 г.
вторник, 23 марта 2010 г.
Pharmaceutical company Eli Lilly as Hollywood suffered looting $ 75M loss
Enfield, Connecticut, was the largest robbery in the history of drugs, loss of $ 75 million on prescription antidepressants and antipsychotic funds. This happened on the security guard industry. There are no suspects and no leads have been announced. We know the investigation continues, and few facts.
In the early morning hours of 14 March staff based here for the pharmaceutical company Eli Lilly-producer of prescription drugs such as Prozac, Cymbalta and Humalog-was broken by an unknown number of thieves. Wine Cut through the roof, somehow circumvent the system ADT security and to let go a warehouse where they found time removing the robbery. Published reports say the operation should have lasted an hour and ended with the thieves stealing at least ten and probably more trays of antidepressants and antipsychotic funds.
Some suggest thieves probably inside help to circumvent system security. Steve Nutt, founder of Los Angeles IP Signaling opinion, taking into account the value of assets in place within the aid was likely. "The insurance company will insist on 60 or 90 second election as the primary and secondary roads. Installation Company shall provide adequate protection facilities and insurance company, as a rule, who signed the specification so that there is no" misunderstanding "MN said in comments on Blog Monitor Security Systems News' This! "Of course, all this would stop the" inside job ", so let's wait to see if it took place here."
ENFIELD D. Deputy Chief on duty, who wished to remain anonymous said the authorities were not notified of the robbery until the end of the day. "We have not responded to Eli Lilly alarm or anything else," said deputy chief. "If they call us to report anxiety, it generates a concession that we will respond and we do not answer, so that from this I must believe that we have not received the call.
ADT spokesperson Anna Lindström said the security company did comment on ongoing police investigations.
Eli Lilly March 18 stolen drug message posted on its website for customers to assure that investigations are continuing, and inform them of specific drugs stolen. "Practitioners, pharmacies and consumers better buy Lilly products only from well-established, reliable and authoritative sources, and should know that a very low price often means that the goods were stolen," reads the message. "In addition, all pharmaceutical products must always be checked for signs of damage or damage caused to purchase and / or use. Pharmacists and other health professionals should not use the product if it was removed from the sealed bottle or container, if the induction media was compromised, or in the case of glass bottles, if the cover lid, appears to have been violated in any Way ".
Drugs stolen include Alimta, Cymbalta, Effient, Gemzar, Prozac, Strattera, Symbyax and Zyprexa.
Anyone who feels they may have relevant information requested to contact the U.S. Food and Drug Administration Office of Criminal Investigation at 1-800-551-3989 or visit www.fda.gov / OCI.
In the early morning hours of 14 March staff based here for the pharmaceutical company Eli Lilly-producer of prescription drugs such as Prozac, Cymbalta and Humalog-was broken by an unknown number of thieves. Wine Cut through the roof, somehow circumvent the system ADT security and to let go a warehouse where they found time removing the robbery. Published reports say the operation should have lasted an hour and ended with the thieves stealing at least ten and probably more trays of antidepressants and antipsychotic funds.
Some suggest thieves probably inside help to circumvent system security. Steve Nutt, founder of Los Angeles IP Signaling opinion, taking into account the value of assets in place within the aid was likely. "The insurance company will insist on 60 or 90 second election as the primary and secondary roads. Installation Company shall provide adequate protection facilities and insurance company, as a rule, who signed the specification so that there is no" misunderstanding "MN said in comments on Blog Monitor Security Systems News' This! "Of course, all this would stop the" inside job ", so let's wait to see if it took place here."
ENFIELD D. Deputy Chief on duty, who wished to remain anonymous said the authorities were not notified of the robbery until the end of the day. "We have not responded to Eli Lilly alarm or anything else," said deputy chief. "If they call us to report anxiety, it generates a concession that we will respond and we do not answer, so that from this I must believe that we have not received the call.
ADT spokesperson Anna Lindström said the security company did comment on ongoing police investigations.
Eli Lilly March 18 stolen drug message posted on its website for customers to assure that investigations are continuing, and inform them of specific drugs stolen. "Practitioners, pharmacies and consumers better buy Lilly products only from well-established, reliable and authoritative sources, and should know that a very low price often means that the goods were stolen," reads the message. "In addition, all pharmaceutical products must always be checked for signs of damage or damage caused to purchase and / or use. Pharmacists and other health professionals should not use the product if it was removed from the sealed bottle or container, if the induction media was compromised, or in the case of glass bottles, if the cover lid, appears to have been violated in any Way ".
Drugs stolen include Alimta, Cymbalta, Effient, Gemzar, Prozac, Strattera, Symbyax and Zyprexa.
Anyone who feels they may have relevant information requested to contact the U.S. Food and Drug Administration Office of Criminal Investigation at 1-800-551-3989 or visit www.fda.gov / OCI.
среда, 17 марта 2010 г.
Pharmacists need more funding too: PSA
Pharmacists need similar support for the millions invested by the federal government in the training of new doctors, the Pharmaceutical Society of Australia (PSA) called.
The Federal Minister for Health Nicola Roxon yesterday announced a boost of $ 632 million of funding over the next 10 years to train a GPS for 5500 extra and 680 specialists, and provide pre-vocational places 5400 generalist training, doubling the number of practitioners in these positions.
"He can not really be a higher priority than funding the lifeblood of the system, which is our doctor," Ms Roxon told Sky News yesterday.
However, as the president of PSA Warwick Plunkett, the government should not neglect the other primary care professionals such as pharmacists.
"The decision to strengthen the ranks of doctors and encourage people to become generalists is a very positive first step in improving the system of health care and, indeed, in the implementation of reforms in health which are the basis of the government program, "said Plunkett.
"But other professions, such as pharmaceuticals, which are equally crucial for the team of primary health care should not be forgotten. It must also be a priority given to the needs of those professions so that the effectiveness and sustainability team of primary health care model is assured. "
Mr. Plunkett said the government needs to provide more financial support to attract pharmacists in rural and regional areas and ensure they were able to operate effectively.
"The needs quite unique pharmacists in these areas must be recognized and treated by the government," he said.
The Federal Minister for Health Nicola Roxon yesterday announced a boost of $ 632 million of funding over the next 10 years to train a GPS for 5500 extra and 680 specialists, and provide pre-vocational places 5400 generalist training, doubling the number of practitioners in these positions.
"He can not really be a higher priority than funding the lifeblood of the system, which is our doctor," Ms Roxon told Sky News yesterday.
However, as the president of PSA Warwick Plunkett, the government should not neglect the other primary care professionals such as pharmacists.
"The decision to strengthen the ranks of doctors and encourage people to become generalists is a very positive first step in improving the system of health care and, indeed, in the implementation of reforms in health which are the basis of the government program, "said Plunkett.
"But other professions, such as pharmaceuticals, which are equally crucial for the team of primary health care should not be forgotten. It must also be a priority given to the needs of those professions so that the effectiveness and sustainability team of primary health care model is assured. "
Mr. Plunkett said the government needs to provide more financial support to attract pharmacists in rural and regional areas and ensure they were able to operate effectively.
"The needs quite unique pharmacists in these areas must be recognized and treated by the government," he said.
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